Sleep Apnea
Sleep apnea is a top-level condition because sleep quality/lack of sleep appears to exacerbate UC/proctitis symptoms and may contribute to systemic inflammation.
Current UC/proctitis relevance
New canonical mechanism page:
Current working interpretation:
- Poor sleep, untreated sleep apnea, intermittent hypoxia, and circadian disruption may lower UC/proctitis barrier reserve through inflammatory cytokines, intestinal permeability, dysbiosis, motility/autonomic shifts, and impaired repair.
- A 2025 prospective observational UC study found higher relapse in chronic poor sleep: 34.5% vs 10.3%.
- OSA appears more prevalent in IBD/UC cohorts than non-IBD controls.
- For Paul, sleep/apnea may explain why dairy/gluten/stress/stool-contact triggers cross the bleeding threshold on some weeks more than others.
Buildout TODO
- Import relevant Notion/Health Meetings notes.
- Integrate Guava data when available.
- Build personal-history summary: diagnosis, AHI/RDI, oxygen nadir, CPAP/oral appliance status, residual AHI, adherence.
- Build research/mechanism map beyond UC overlap.
- Link to UC/proctitis where mechanisms overlap.
- Track sleep metrics against UC symptoms/labs if data becomes available.