Medical Research Wiki Index

Obsidian-compatible research knowledgebase focused primarily on ulcerative colitis. Last updated: 2026-07-04 | Synthesized pages: ~48 | See SCHEMA for conventions and CLAUDE.md for how to work in this vault.

Start Here

How to work in this wiki (CLAUDE.md) — orientation for humans and LLMs: structure, link rules, safety.
Medical TODOs — action/research checklist for clinician-prep and personal medical follow-up.
Ulcerative Colitis and Proctitis — primary condition hub for UC research, mechanisms, methods, and questions.
Research Dashboard — friendly dashboard for current priorities, open questions, and recent updates.

Conditions

Ulcerative Colitis and Proctitis — primary active condition object (mature).
- Proctitis Care Plan and Routine — active mesalamine/supplement routine and Dr. Snow regimen tracking.
- Proctitis — the evolving causal model.
- Key Insights · Top Research Insights · Key Open Questions
- Community and Forum Watchlist — forums/Reddit/boards monitored for anecdotal cure/remission reports.
Sleep Apnea — sleep quality/inflammation overlap (scaffold).
High Cholesterol — lipid/gut-liver axis (scaffold).
Silent Reflux — upper-GI condition object (scaffold).

Symptoms

No standalone symptom pages yet. Symptom patterns (mucus-first onset, constipation→blood sequence, tenesmus) are currently tracked in personal-history and central-theory.

Interventions

Interventions are currently organized inside the UC condition object rather than as standalone pages: see Proctitis Methods and Current Care Plan, plus the intervention-flavored mechanism pages (mucus PC, constipation-safe fiber, beneficial commensals, FMT, nicotine) below.

Mechanisms

Proctitis-First Onset Mechanism in UC — why UC starts in the rectum: mucus barrier, PC gradient, contact-time, distal ecology.
Delayed-Release PC Barrier Repair in UC — mucus-PC barrier failure, delayed-release PC evidence, formulation caveats.
Thiolase Branch in UC — thiolase impairment, butyrate oxidation, H2O2/redox stress, Pravda/Roediger claims.
Pelvic Floor Mechanics in UC Proctitis — UCAC, fecal stasis/contact time, tenesmus, pelvic-floor mechanics, local rectal therapy.
Full-Evacuation Strategy in UC Proctitis — kiwi, psyllium, PHGG, resistant starch, PEG, toileting posture, complete-evacuation tracking.
Microbial Positioning in UC — microbes/toxins in the wrong mucus-layer location: Aeromonas, Fusobacterium, SRB/H2S, Akkermansia, R. gnavus.
Butyrate Ecology in UC — F. prausnitzii, Roseburia, EcN, De Simone/VSL#3-style probiotics, psyllium.
Wheat Food-Trigger Mechanisms in UC — dairy/gluten/wheat trigger branch and low-reserve rectal barrier threshold.
Non-IgE Dairy Hypersensitivity in UC — milk-protein allergy/hypersensitivity, oral tolerance, eosinophils, lactose.
Circadian Disruption as UC Barrier Amplifiers — sleep/apnea/circadian disruption as a barrier-reserve/inflammatory-threshold controller.
Gut-Liver-Lipid Axis in UC — ALP/cholesterol flare-tracking, PSC screening, intestinal ALP/LPS biology, bile-acid/lipid signaling.
Functional Distal Microenvironment in UC Proctitis — the H₂S/indole/SCFA/contact-time target state rather than a generic “better microbiome.”
Microbiome Transfer in UC — FMT as a direct test of the microbial-ecology hypothesis; three positive induction RCTs (clinician/trial pathway, not DIY).
Smoking Paradox in UC — nicotine’s induction-RCT evidence and the non-smoker paradox as an autonomic/mucus clue (not an endorsement of smoking).

Medications and Supplements

No standalone drug/supplement pages yet. Current regimen (mesalamine enema/suppository, Dr. Snow supplement stack) lives in Current Care Plan; a berberine/omega-3/glutathione shortlist is in the supplement-shortlist find.

Clinicians and Sources

Clinician/coach/community indexing lives in UC Coaches and Influencers and Community Watchlist for now.

Anecdote Syntheses

No standalone anecdote-synthesis pages yet; anecdote monitoring is in community-watchlist and the weekly community digests under the journal.

Comparisons

None yet.

Queries

None filed yet. Substantial answered questions get filed under queries/ per SCHEMA.

Journal

Research Journal — chronological inbox for weekly digests and new finds before promotion into condition pages.