Web provenance for UC pathobiont/mucus-layer digest 009
Aeromonas/aerolysin Science 2025 press coverage
- EurekAlert: https://www.eurekalert.org/news-releases/1106181
- Medscape: https://www.medscape.com/viewarticle/toxic-bacteria-spur-colon-inflammation-ulcerative-colitis-2025a1000wgk
- Study title: An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
- Journal: Science
- DOI: 10.1126/science.adz4712
- Date: 2025-11-20
Key extracted claims from press summaries: aerolysin-producing Aeromonas variant selectively killed intestinal macrophages, worsened colitis in mice, mutant strains lacking aerolysin did not, anti-aerolysin antibodies alleviated mouse disease, and a 574-person clinical survey reported Aeromonas species in 72% of UC patients vs ~12% healthy controls and nearly absent in Crohn’s disease. Treat as high-interest but needs direct full-paper review/independent replication.