UC/Proctitis Journal Highlights
Promoted highlights from the chronological Research Journal will go here.
2026-06-17 — Causal mechanism digests
- Digest 001 — Barrier, Mucus PC, Redox, ALP, Coconut Water: moved mucus phosphatidylcholine, colonocyte redox/thiolase, microbial niche, coconut water RCT, and gut-liver-lipid signals into the central theory.
- Proctitis First: upgraded the central theory to model rectal-first disease as a low-reserve/high-contact distal barrier-threshold failure.
- Digest 003 — Dairy, Milk Protein, Gluten, and Wheat Triggers: added dairy/gluten/wheat as personal trigger/amplifier nodes and included a full source-audit table.
- Digest 004 — Sleep Apnea, Poor Sleep, Hypoxia, and Circadian Disruption: promoted sleep/apnea/circadian disruption as a barrier-reserve and inflammatory-threshold controller with relapse, OSA, permeability, calprotectin, TNF-α, dysbiosis, and melatonin signals.
- Digest 005 — ALP, Cholesterol, Gut-Liver-Lipid Axis: promoted ALP/cholesterol as objective biomarker clues; added ALP isoenzyme/source logic, PSC clinician-screening questions, intestinal ALP/LPS/barrier biology, bile-acid signaling, and lipid-pattern contradictions.
- Digest 006 — Mucus Phosphatidylcholine and Delayed-Release PC: promoted mucus PC as a core barrier-repair branch, while marking delayed/modified-release PC intervention evidence as hopeful but mixed and formulation-specific after LT-02 trial results.
- Digest 007 — Redox, Butyrate Oxidation, Roediger, and Pravda: promoted redox/butyrate/thiolase as a root-cause-grade branch while safety-filtering Pravda/RDLA/STS claims and explicitly flagging H2O2 enemas and chlorine dioxide/CDS/MMS as danger/avoid categories.
- Digest 008 — Constipation, Contact Time, Pelvic Floor, and Local Rectal Mechanics: promoted UC-associated constipation/contact-time/pelvic-floor mechanics as a core personal-pattern branch and added 46% UCAC cohort signal plus pelvic-floor behavioral treatment signal to top research insights.
- Digest 009 — Pathobionts, Mucus-Layer Ecology, and Microbial Positioning: promoted microbial location/virulence-factor logic; added Aeromonas/aerolysin emerging subgroup signal, Fusobacterium oral-gut caution, SRB/H2S link, Akkermansia/R. gnavus context-dependence, and stool-test limitations.
- Digest 010 — Beneficial Commensals, Probiotics, Prebiotics, Butyrate, and Fiber: promoted beneficial butyrate ecology as the counterpart to the pathobiont branch; added F. prausnitzii/Roseburia, EcN, De Simone/VSL#3-style probiotic, psyllium/Plantago, fiber-tolerance, and mixed direct-butyrate evidence.
- Digest 011 — Constipation-Safe Prebiotics, Fiber, Food Methods, and Full Evacuation: promoted contact-time-first constipation logic; added kiwi, psyllium/fiber meta-analysis, PHGG, resistant starch, 4-SURE, AGA/ACG constipation guidance, footstool/posture, and pelvic-floor/outlet testing strategy.
Future weekly internet scrubs should first write to journal/weekly-digests/ or journal/finds/, then promote important findings here.
Highlights
To be populated after the first weekly research scrub and after digesting the existing Notion source queue.
2026-06-27 — Scite validation pass strengthened the central theory
- Digest: UC Central Theory Scite Validation Pass
- Main validation: the MUC2 mucus-barrier/spatial microbial-positioning model, UCAC/contact-time branch, sleep/circadian threshold branch, redox/butyrate branch, and beneficial-commensal ecology all held up under scite search.
- Biggest new idea: target the functional distal microenvironment rather than generic microbiome labels — lower H₂S/indole/protein fermentation pressure, support SCFA/butyrate ecology, preserve mucus exclusion, and reduce stool contact time.
- Promoted top insights: 4-SURE functional profiling of sulfide-reducing diet; IAP/SRB/Snail barrier-leak mechanism.
- Safety frame: scite validation does not justify DIY antibiotics, FMT, redox/enema protocols, or high-dose fiber jumps.